Exodus will kill Mass Effect forever.

In some cases, it's because some creators don't know how to run a business regardless of whether it's a video game company, movie studio, music company, or a comic book company. Some creative people can but it's often after a long and painful process of learning about their creative field from the other side. Image Comics is a perfect example of this, back in the 90s 6 of the hottest comic book creators left Marvel to start their own company Image originally as an imprint of Malibu (an independent publisher) after about 6 months they left Malibu and became fully independent the only problem only one of them, Jim Valentino, had any kind of knowledge of being an independent comic book publisher all of the books were constantly late and other creators they originally brought in to help them write, pencil, ink, color, letter, and edit their comics didn't get paid and/or they just sucked. Many of the other creators who had come to Image to publish their own books left and started their own companies because of the extreme competition with the founders whose egos got out of control and started as many fights as possible with other creators like writer Peter David and John Byrne who both feuded with Todd McFarlane, who were critical of their books and their attitudes. Honestly, I don't know how Image Comics is still in business, but at least two of the Image founders are out of Image; Jim Lee sold his characters to DC and is now one of heads at DC. Rob Liefeld lost the rights to most if not all of characters, and he seems to be more of high-priced freelancer now of days.

I think some of the creative people in video game industry are going to be the same way.