There is a way around the ME3 multiple ending problem.

How about, say, the yahg advancing and eventually overrunning the galaxy regardless of what Shepard did and fighting a great war in that results in annihilation of the old MW species (humans, quarians, asari, turians, etc.) so that we can't if they were synthesized or not (or perhaps the game could recognize the ending by finding an occasional survivor of the old species that would appear with glowing green eyes only if synthesis was chosen).  The MW we return to though is mostly yahg (who were, due to some difference in their genetics, immune to synthesis) and newer species that emerged and advanced in that 600 to 1200 year period we've been gone... perhaps some who want to overthrow the yahg and who could become new alien allies.  Perhaps the difference in the yahg could be as simple as "they weren't ready" to accept synthesis... and the reason synthesis failed in the past is that genes that are not ready to accept the merger simply reject the "transplant."

How does thist make everything in the OT meaningless?  Making it not exist by redoing the OT in a different way with a different ending ist what makes the OT completely meaningless.  This makes the OT and Shepard, however each of us created/played him/her, part of the history of the galaxy going forward.  The only thing it doesn't do is make that history animated within the present story (whenever it takes place).  It acknowledges it instead in words inside data logs.  It utilizes species and images already in the OT.  The yahg, who go nowhere really in the OT, become the next super-enemy, since in any ending except destroy, they would have to have destroyed the Reapers themselves before taking over the galaxy... maybe they allied with Leviathan.  It also works for refuse because the yahg are destined to survive into the next cycle anyways.  If destroy, the yahg go to war against the humans and other Milky Way species and take over the galaxy from them..

Also, it's not my job to actually write the exact story going forward... and I know whatever suggestion people come up with is just going to get torn apart because the bottom line here is that portions of this fan base are bent on one thing and one thing only... Bioware screwed up the ending to ME3, so they need to fix it.  It's a fan base unwilling to move forward, period.  I also bet that if a redo of ME3 is done by anyone... a number of the fans still won't be happy with it.  The new trend is to basically rip any new game apart, AFAICS.

The fact is Bioware already chose their way around the ME3 multiple ending problem - they wrote Andromeda.   Beyond and through Andromeda... anything is possible to come from them.  They're writing the story, not us.

Who said what Shepard did wouldn't have substance.  It would certainly have more substance than if they remake the Trilogy and completely wipe 3 of 4 ending choices right out of the history or even write out 4 of 4 ending choices.

With this, each ending could be acknowledged... just not "in your face" visually and it would just be that time erased the visual physical evidence of it.  Which happens in most things as time goes by anyways.   Nothing is forever; that's why we have archaeology.  The player's choice can be referenced in a sequel fairly cheaply since what you find in the form of records and artifacts can change to reflect the endings you chose.

I'd be just as happy to just continue on in Andromeda and continue with the story they started in the first game there, with Ryder as the protag.  I liked the game and would love to see it continue.  I believe though that they planned for us to go back eventually to the Milky Way... Mac Walters said as much in an interview.  I think they should continue with their story as they planned it and ignore the likes of us who have likely never written an award-winning game trying to tell them how to write theirs.

I don't suppose it helps that I made a typo in the part you quoted.  It should read "IMHO better than choosing one canon.  In principle, I really respect Bioware for not welching out on a choice they gave us but instead writing a sequel game that still preserves all of those endings.  I'm not going to a tantrum if they opt to choose a canon.  It's their choice to make, but I will lose some respect for them... Specifically, the respect that they gained by not reneging on those choices.  I think that's appropriate.

What ending I prefer is, IMO, totally irrelevant to the discussion.  Different people did prefer different endings.  No ending is unanimously the preference.  There may be a majority that prefer the destroy ending, but I don't think that should give them the right to bully Bioware to renege on the other choices.

I also believe that they should stand by their chosen method for getting around the issue.  It's done... we ARE beyond the problem and we should just move forward.  That Andromeda itself was imperfect is again, irrelevant.  Fans constantly requesting do-overs because they didn't like this or that about the games that have already been written does not get us anything new and exciting... it just mires us down into playing the same old games over and over again in slightly revised forms.  What I really want is for the franchise to now move forward from where it's at... which is in Andromeda with the Initiative now in possession of Meridian.  I want to explore something new... not redo anything.  Bioware had a story planned that got around the ME3 endings when they wrote ME:A and a plan for future games.  I think they should stick with THEIR plan... whatever it was.