Interesting excerpt from Mac interview regarding Andromeda as a series and where it's going next

Destroy - Salvage Reaper tech, advances but gets unstable, you get sense they advanced the relatively least but averted bigger dangers
Control - Reapers around, gets destabilized, you get sense they advanced more but eventually experienced some bigger dangers
Synthesis - Ascended galaxy, advances the most, some story factor collapses them, you get sense they advanced the most but experienced the biggest dangers that exploited them when reaching beyond
Refuse (if part of canon) - Does not advance, but the harvest occurs in a way that isn't as straightforward as we'd assume, resulting in something close enough to work with the other results (Reapers, MWers present); story is set up that a 'harvest' will still 'happen' far in the 'future' by 'Reapers' but the nature of it will be again rather different than we'd straightforwardly assume (*insert complicated lore*)
All - Galaxy is wrecked centuries in future and Reaper-ish stuff around (possibly mostly renamed), everyone alive is still organic, but of a techy nature like we're already being set up like Angarans, and they managed all sorts of progress in their own ways that provide some insight on broader concepts.

Shepard:
Normal - Ending more or less happened as we saw it, there was Crucible effects and our experience was mostly reflective of 'reality'
Indoctrination - Shepard was in a mind twist in the ending of ME3 and whatever we saw, at least as him, wasn't always entirely reflective of what was 'actually' happening; he's still resistant though and never fully succumbed to anything - game was always some victory but we're always lacking some level of detail and context that future story can reveal or elaborate
More - The things we learn in MEA+ explain how interfacing with synthetic entities isn't exactly the same as what some guy (Saren) and previous terrified and reaped cycles called/considered 'indoctrination'.


MEA:
We eventually go back to the Milky Way due to a disconcerting silence from it, it probably had its good times (which flashbacks and timey wimey and character accounts and side stories may very well reflect), but is now in a bad time, and we are unsure whether to consider them allies or enemies, same with considering the more alien folks from the Andromeda galaxy. In the end, a basic 'kill from giant robots' story becomes something of more complex politics as organics try to manage evolving without becoming their own (past/present) enemies themselves.


Destroying things always happens, its a damn shooter, its gonna happen and follow a story of might makes right, of us destroying things and them destroying many of us (or if the series get daring, in some sense managing to destroy us but the story continues).
Controlling things is always a potential, there's always controllers and we always learn how much we can control.
Synthesizing things is inevitable but like the other ME3 endings, it doesn't have to happen in this form, and we can learn how other parts of the cosmos dealt with such a concept that the Reapers found impossible to fit their desired solution.


I do think Mac loves Synthesis, but I don't think its for the reason many people assume or at least lean towards. I think he is just posthumanist and injected that in since at least ME2, and this doesn't mean its good or bad, but simply a considered very likely destiny for our species if given enough time (decades, centuries, more) to develop technology. So it isn't that 'Synthesis is good', but more a mix of 'Synthesis is best result ending' and 'Synthesis concept is inevitable'. The *action* of Synthesis, however, is actually not painted to me as the right/correct decision, even if its one we can take. It has a highly eerie tone and plenty of warnings against anything like it. I don't think a post-Synthesis galaxy is just fantastic and utopian, and I don't think ME3 intended that. It is simply a vision of the future (not an EXACTLY ACCURATE one), and what provides the most immediately positive results for the galaxy (but provides a FREAKY feeling at the same time). There's nothing in the narrative given to make it fact that it must continue on like that, and so far, I can easily imagine it collapsing because its such a new thing that no one knows that to do with it even while considering themselves synthetically enlightened.

It may have been a minority of players, but Genophage Full Cure had a few players freaked out about this being a fake-out and enabling the Krogan to be a bigger threat than ever (even if handled nicely in many ways by themselves and others), and many players freaked out about Rannoch Peace, especially with the already side-hint of Geth integrating into Quarian suits whilst we have a warning from an optional character (Javik) about how such a thing could be highly exploited. Nothing necessitates a millennia-long super golden age for either Krogan or Quarians no matter what we do - we just provide the dream, the new possibilities. Not the tangible results. Shepard is only good for that in destroying things, that's his story.



I put it this way - if I want the nicest result for everyone by a Shepard who in ME3 has undertaken a sense of having to be a space messiah (which is believable enough if they either suffered a ton or suffered the least possible; for different reasons), I'll go with Synthesis. If anything else, I see plenty of valid reasons to go for the others. Control for theoretical knowledge and accepting new information and Destroy for practical knowledge and common information (and against the Reapers, that's the 'right choice', but I don't need to RP this as the story for my Shepard).