Do you think we might ever return to the Milky Way?

No i don't think they should. The ending was a trainwreck and they would have to set a canon in order to make it work and that would cause all sorts of fallout. At most they should establish communication with the Milky Way from Andromeda which could potentially be doen whilst still respecting any ending being canon.

In the future? Sure.

But not in a close future...

Yes

The details have changed. It happened so long ago. Ok. One more story.

I doubt it... if the franchise lives long enough, we might see a game set around an earlier point in the timeline, but the Andromeda "arc" (if it becomes one) will probably stay in that galaxy. The fact that we only have seen one star cluster of this new galaxy so far also speaks to that. Once humanity is established there (probably after MEA), they could go on making numerous games from there...

They could. The Catalyst said synthesis would eventually happen in a distant future, no matter what ending Shepard chooses. By the time Ryder arrives in Andromeda synthesis could already be a thing in the Milky Way, who knows. I doubt fans would be happy though.

That's why I think we won't get back.

It was pretty obvious at the time that this was a total end for the franchise, since we could scorch whole fixtures in the setting. 

Yes.

I want them to have the balls to make the destroy ending canon and then have the former Andromeda Initiative send an expedition through a wormhole back to the MW. Only to find out that the Yaahg are ruling the galaxy and only a small resistance of the other Milky Way races is left to fight them.

Actually yes and there is simple reason for that yes.

For the state of the Milky Way to "stabilize" after whichever ending of ME3 might have been canon, they need many centuries for its effect to "dissipate".

Flying to Andromeda already takes over 600 years, assuming that we cannot find any way in Andromeda that would let us eventually go back and forth instantaneously... another 600~ years or less/more need to pass, if we go back.

So, that is at least over 1000 years on average to go back and forth once - a lot of stuff could have happened in the Milky Way in that time, that could make any of the ME3 endings either irrelevant or "just history".

That is how I see it, they can be laying groundwork for future ME set in Milky Way, but after the events of ME:A.

...

Besides, the whole AI is described as an Initiative to find a reliable route connecting Milky Way with Andromeda.
Whether this is just a "propaganda" behind AI or an actually honest intent behind AI is yet to be seen after release.

I feel that going with destroy would face the least resistance. Synthesis is easily the shittiest lol

Maybe after they write themselves into a corner in the Andromeda galaxy...

If we were to go back to the Milky Way, it would have to be some sort of post-apocalyptic reboot to purge all of the Ending-related stuff.

They've said none of the three endings are canon, so the only way I see them returning to the Milky Way is if the "Refuse" ending was canon. Which could be quite interesting.... And probably depressing as we learn how our ancestors slowly fell to the Reapers!