The Genophage

We need to make the genophage great again!
Make it 0.5% only, and hold all fertile females hostage so the krogans will do what they're told, like the good cannon fodder they were always meant to be.

More seriously, having all the krogan from the same clan seems to me what is changing their prospects. As soon as internal turmoil and war starts, they'll be endangered species again.

I think they handled it well lore-wise. They didn't magically cure it to align with ME3 decisions yet they made it a bit less of an immediately pressing issue like in ME3

I mean, I don't understand how dark energy can be a cloud with mass, but there it is. 

As for choices, I'm not sure how a decision Shepard made after the Arks left would affect the Krogan in the Arks. I'm fairly sure it follows along with what Mordin tells you in ME3, too. The Krogan were already adapting and the genophage was no longer working or no longer as potent, and the Krogan used their time in the Arks to further the mutation.

From a purely meta-game perspective, it makes sense to have the world carry over in the same state it was at the end of ME2. And what's also true is that there are thousands and thousands of real-life humans who would say yes immediately to leaving for another galaxy and colonizing it. The galaxy had been scanned and possible "Golden Worlds" were picked out of that information, which is why you land where you do. Your trip to Andromeda has nothing to do with the Reaper invasion, it's purely to explore. It's the same reason explorers crossed oceans. I actually like that the Andromeda Initiative had nothing to do with saving species from the Reapers.

So yes, it does make sense that Shepard's ME3 choices don't carry over, because the Arks were already gone.

Because stasis doesn't mean they're completely frozen stiff.  They'd be dead if that were true.  It's much more likely that they were put into a state where bodily processes were slowed to a comparative crawl.

Well, there are drugs that slow your bodily processes down, so it's a pretty good guess.

when you have to do mental hola hoops to explain your lore than you know somethings wrong.

Ok but that doesn't address the main issue - the krogan adaptation spreads through the cells in those 600 years. If the body is hibernating, the cells are almost paralyzed, just active enough to keep the system alive.

In that state i don't buy into cells mutating or reproducing, creating new ones that are genophage-resistant. The natural resistance came from natural evolution, lots of cells being created and destroyed, being frozen would stop any kind of cell development or mutation.

That's like doing gene therapy to a frozen organ to cure a disease - it just wouldn't work

It's interesting learning how the genophage was starting to fail (which we already knew since ME2) but I'm curious to see how this will be useful to them. Let's assume everything had gone as planned, all the arks arrived, and the golden worlds were ripe for colonization. Then assume the krogan choose one world for themselves. Then they start breeding at 100% efficiency. Where do they go? Do they overtake the other 6 golden worlds? Become conquerors of the natives of Andromeda? It's sketchy, at best, to assume this would work out for them. I like the idea of increased fertility/viability to give them hope but not a full on cure. (Yes, this contradicts my position in ME3, but I think there's enough non-Council space to go around for them.)

I think this is where the percentages are important. Three to four percent increase in viability, which sounds like a much more sustainable birth rate. Not sure if it will stop there, or continue to rise as generations adapt, but I really don't want to have to make a decision about the genophage again.

From what i understood Krogans can have a ridiculous birth rate if left unchecked without genophage, it is quite a worrysome thing since i also chose to sabotage the cure in me3, Wrex and Eva might be good but they are just 2 krogan, sooner or later they will die and there are no guarantees the successors wont fall to the trap of krogan rebellions again.

So if they start breeding a lot there is a chance they could become an issue, though maybe andromeda had different screening procedures and took the more calm and intelligent ones which suggests there is hope. Guess we will see in the game.