Things that don't make sense (v2)

. The Catalyst says that organics and synthetics can't live together in peace, and if you've brokered peace between the Geth and Quarians then you've already proven him wrong, so what is the point of Synthesis and why trust the Catalyst?

3. There is no guarantee of peace, despite what the Catalyst says, just peace between synthetics and organics and only because there will no longer be such a thing as synthetics or organics anymore. There will only be hybrids, and hybrids can still war with each other.

4. Assuming that the Catalyst is right and that there will be peace, the only reason there is peace is because of forced homogeneity.

1. We know that the Krogan Rebellions lasted decades and that it was because of an unchecked population boom post-Rachni War.
2. Because of the nature of Krogan physiology (biotics, long life, and backup organs), the Rebellions were especially violent. They used asteriods as weapons and rendered three Turian worlds uninhabitable. And because of the high Krogan birth rate, they essentially have unlimited troops.
3. EDI tells us that a Krogan female can give birth to 1,000 eggs, and if that birth rate remains stable, that over 10 million Krogan can be birthed in single generation.
4. We know from Mordin that the genophage is not a sterility plague, but a method used to reduce the Krogan population to pre-spaceflight numbers.
5. We know from Wrex that the Krogan themselves have no interest in curing the genophage.
6. We know from Mordin that the Krogan have demonstrated no interest in concentrating on breeding to keep population numbers stable. The violent nature of the Krogan is borne out is every codex entry and almost every conversation you overhear between Krogan. From the Mass Effect wiki: "Given the prodigious krogan birth rate, it would appear that the enormously violent nature of krogan culture is actually responsible for their dwindling numbers."
7. It's irresponsible to assume that the very nature of the Krogan culture will change because of Wrex and Eve. The blood rage isn't going away, nor will the need to fight a thresher maw to become an adult.
8. Assuming Wrex and Eve are alive in ME3, what's to stop Wrex from being killed by another warlord or clan that isn't taking too kindly to restrictions on birth rates? We shouldn't forget that Wrex's own father tried to kill him, so there's no reason another clan won't try.
8. The safest assumption Shepard can make is that sure, he can cure the genophage, but that once the Reaper threat is dealt with, the galaxy will likely have another problem of what to do with the ever-increasing Krogan population. So, the exact same ingredients that led to the Rebellions in the first place.