If there was one major thing you could change about this game, what would it be?

No SAM. At all. Period.

Either playing as another Pathfinder, or having TWO critical path through the game - as a Pathfinder Ryder or an Exile Vidal that finds an alternative way to kick-start the Vaults from Remnant and Angaran tech after taking Sloane down with an option of a darker, more brutal protagonist. 

Nexus carrying a few non-council races so the cast is not restricted to the 4 races only (and that includes Tempest crew). 

Quarian Ark story-line in the game. 

I'd dial back on the SAM notifications and...nope, that's about it.

Moar Music.

Set it in a remote corner of the Milky Way far off the relay network.

A broader spectrum of dialogue options/tones, and reworked cinematics, including a better use of the music.

Oh jeez, I've gotten so used to it I completely forgot about the stupidity of disabling saves.  WHY WHY WHY WHY?

Gut the character creator and just give us the one from DA:I but better.

Big risk taken to tell a bold, new ME story and create unforgettable characters. This game's a little too safe.

Change the price to $5 and refund me the difference so it feels like I got my money's worth.

There are some many deep problems with Andromeda that is hard to pick just one, especially because they are all connected.

I would have the quests directly effect the settlements you put down on the particular worlds, and have the settlements expand or change over the course of the game based off what was studied, found, acquired, accomplished on said quests.

That way you could actually see the fruits of your work, and see the initiative succeeding and expanding in the Helius Cluster. All we get is a viability percentage that really means nothing in the grand scheme of things.

This also would eliminate the fetch quest feel of the game, and cause players to want to do more quests because they would be looking forward to seeing what they would do to their colonies. It also would confine more quests to one planet and eliminate a lot of the system hopping and having to sit through all the scenes.

It would also give more meaning to which pods you opened up. Science, Commerce and Military could have offered different things to the growing settlements. It would go towards replayability as well.