Mad Scientist Bro!Ryder needs some suggestions.

Remnant Scattershot built with shield oscillator and Plasma charge, you want to reduce the amount of shot per clip to 1 (it recharge super fast). That means either using the low ranked Scattershot research version + mod that reduce clip size or using the Fusion Mod of Rupture (which increase weak point damage against reduced clip size, so that actually increase DPS).

With each use the weapon will grant you 25% shield restore. That means you can pick Lance with the "eat shield" evolution and basically go lance + scattershot+ lance + scattershot. Pick another ability that prime enemies (singularity, annihilations, cryo beam, flamethrower, etc) and you are got to go for exploding madness all around as lance is a detonator.

As a bonus, the plasma charge version throws lots of exploding particles everywhere and long range accuracy is among the best for shotguns.