How will the game start?

But their destination can be calculated from the route they take . Once the Reapers find it they would simply need to jump there and wait since they move faster at FTL.
So I believe it's unlikely the game would start during the Reaper War.

Anyway, i think it will start inside the Arc Ship with the protagonist not knowing if he/she reached Andromeda.

What I'd like to see and what I think we will actually see are oceans apart.

I'd be happy with a cgi opening scene with the different species getting on shuttles and lifting off from their planets and flying to meet the Ark ships with a voice over explaining how the galaxy is under serious threat, a threat we are not sure we can beat, and that under the guise of an exploration mission (so as to not cause mass panic) all the galaxies governments had agreed in secret to send enough people to ensure their species survival. *images of mixture of races loading onto the Ark and into pods*

Then something along the lines of the Arks firing up into FTL, leaving us staring at empty space, then the voice over saying 'we left just in time' then just the trumpety blargh noise the reapers make, then cut to ME:A logo.

Then a tracking shot of pods until get come to Ryder then CC then 'we arrived' scene.

Ehhhh, kind'a but not really. Those kind'a distances are so hard to tell by the angle of the ship in 360 space, simply because of .0001 difference can mean about 5-10 star systems.  And that's on one axis.  Take into consideration that there are three axis --  Then multiply them all by each other, you're all of a sudden looking at 30 to god knows the calculations...    I know it's high though.

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How do you figure?
The ARKs are not using standard FTL drives because they arrive in Andromeda in 600 years.  So, all the restrictions like discharge cannot be applied.  The only
way to avoid any existing canonical restrictions is to re-write the rules or create a "FTL discovery". Here is where the prequel novel comes in to re-write those canon texts.

I don't see the game explaining the canonical changes. That is not the function or purpose of the game.

This math checks out.

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Speculation? Of course!
That's why we have these boards....

Well, a lot of it will have to do with who the enemies are in the MP. If the reapers are introduced, they will be in the MP. So, I'm guessing that we are fighting off Cerberus. Another reason for my theory of starting from Sanctuary.

I don't think we will see the Milky Way at all ( and I personally prefer if we don't... )

My bets are on seeing the Hyperion floating in the space, then the camera goes inside showing different deactivated levels, all silent, and then how the ship starts activating them. More zoom in and character creator shows up.

The information we have so far makes me think that we won't be thrown into action right away, that would mean that as soon as we enter Andromeda we run into a space-faring species that doesn't like us arriving there... unless the "action" comes from the ship itself, who knows, may be something breaks and cannot be repaired by automated means. I discard conflict between the passengers since everybody is supposed to be in stasis...

We don't wanna forget that "600" was considered a good guess, not the actual time. It's just as likely, taking the Black Ark theory into consideration, that it'll take less time. Even if the theory isn't used, they're bound to have found something from the Collector's which'll be similar in tech from when the group Vega was in gained Collector data during ME2's timeframe.

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Good point.

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Walters:
I think you can infer that the voyage and the effort to do this is not a task that anyone would've taken lightly. If you think about a process where you go to sleep and then 600 years later and you wake up, but for you, no time has passed, the last thing you'd think before you go to sleep is, "Are we going to make it? Am I going to survive this? Will the ship just implode somewhere along the way? So we actually wanted to capture that moment of, "Oh my god, we're here!" That's really where this story begins.

link: www.rollingstone.com/culture/features/how-bioware-plans-keep-mass-effect-andromeda-game-true-to-roots-20160620