Is anything from the original trilogy going to matter?

But why? This is a soft-reboot. It borrows the essential lore from the original IP and takes it with to the next generation of Mass Effect and then focuses on Andromeda as a new setting. The whole point of this game isn't to reconnect with Milky Way (despite stating that this is the Ai's goal). If that ever happens it's the sopranos fade-to-black ending. The point of this game is to recreate Mass Effect with no strings attatched and to redesign it for this era of video games. It's like a second-wind of the franchise.

It's like Batman Beyond. If we're lucky maybe they can make a Return of the Joker but preliminarily it's not the point to move away from the original canon only to reconnect with it in the same game that tries to establish and focus on the new lore of Andromeda.

I honestly thought Witcher 3 had Mass Effect 3's way of tackling past choices. Letho's involvement was super cheap and other choices just have you reunite with an old companion just to find out that they die or leave right away, and they defaulted Vernon Roche as your buddy despite of choosing Iorveth in Witcher 2 just like they always pick Udina to be councilor so Anderson can stay on Earth in ME3's plot (one of the biggest wasted opportunities, all because they wanted to make the save-earth plot)

It was just a good piece of fanservice. After all, the Witcher trilogy isn't a real trilogy save from being 3 games featuring the same protagonist and his friends. The central conflict of TW3 has nothing to do with whatever the story was in TW1 or TW2. I did like how they brought the political developments from TW2 into 3's continuity though... if only they could've avoided making it so terribly one-sided after what they did to Radovid.

You're saying it's a soft reboot.  BioWare isn't saying that.  They're saying there will be references to the trilogy.

You have amnesia and there is no mention of Ciri being chased by the Hunt. You do not know they're out to kill your daughter that you don't even remember and as such the Wild Hunt itself is not the central conflict, nor is the relationship with Geralt and his daughter. The main conflict of TW1 is a fanfic plot where a new kid, Alvin, is the plot of Azar Javed and his Professor companion and the witcher Berengar that has vanished, and in the end of this mystery you face Jacques de Aldersberg who threatened the world with the White Frost or something... lol I can't remember, it's been way too long but it's not the same core conflict as TW2 or 3 because the Wild Hunt is not established as the antagonist until the third game and Ithline's Prophecy isn't the threat that looms over everything.

Lord of the Rings has Sauron and the Ring as the constant force that drive the plot.
Matrix has the machines and well... the Matrix itself.
Mass Effect has the Reapers
Harry Potter has Voldemort.

As a series the Witcher games aren't really a proper trilogy. They're a saga like Andromeda is allegedly going to be (if they make a sequel)

I imagine the most we're going to get is references to Saren and the geth, the Battle of the Citadel, Shepard's death/resurrection and the Collector attacks on human colonies.

Well there's probably always the chance that it can be used for something in the future, even a remaster that let you convert the save to PS4s and shit.

All i expect is codex entries along the lines of commander Shepard becoming the first human spectre on such & such a date, Shepard played a lead role during the battle of the Citadel with a multi species crew ( insert crew names & species ) etc, there'll be no mention of Shepards gender because there's no need to mention it, that & it would be easier for them if they didn't mention it, & i don't expect nor frankly want any thing more than that.