Moments that made you laugh

Go to the bar at the casino. You have one conversation with Wrex (if he's alive) and one with Joker there.

Head butting a krogan warlord ....

Oooo my femshep has head butted a few krogans in her time.

Joker: Hey, Jack, now that you’re military, you gonna wear a uniform? Or are you just getting the officer’s bars tattooed on?

Jack: Screw you, f… flight lieutenant.

Joker: Uh… what the hell was that?

Kahlee Sanders: Jack has promised to watch her language in order to maintain the necessary professionalism we need from our teachers.

Joker: What, does she have a swear jar or something? ‘Cause I bet if we emptied that thing, we could afford another cruiser.

Jack: Cover your ears, kids. [pause] Hey, Joker, f—

:lmfao:

Kaidan: What do you know about these mercenaries?

Shepard: They have guns and don't like me!

Kaidan: That's very helpful. Thanks.

Taking Grunt with you when you meet the Biotic God. The look on his face when he walks up to Grunt and says "Fear me!" is priceless.

The sound of Wrex's head hitting the bar while you're discussing his troubles with the newly fertile females. "More ice!"

Grunts arrest in the Citadel DLC, especially him falling out of the hospital window.

Garrus on Surkesh when the Yahg escapes and he says something like "he was muttering T'Soni the whole time".

I forget which option, shooting him in the foot maybe?, but when you hear the announcer on Ilium say Conrad Verner got run over by a sky-car or something

So many fun moments:

1- In ME2 Legion saying windows are structural weaknesses
2- In ME3 Joker saying "those organics wouldn't try the no windows thing twice"
3- In ME3 Legion confirming that the Geth believed his warnings about the Reapers and Shep replying "Must've been nice"
4- Conrad being an expert in xenotech and dark energy
5- Headbutting Uvenk in ME2
6- ME2 "If I know Grunt your answer is coming at muzzle velocity"
7- ME2 "Can't we just take him to Omega and buy him a few dances"
8- ME2 dont remember exact words but Mordin talking about someone on crew contracting a Varren STD
9- ME2 "This is all Joker's fault! What a tool he was, I have to sit all day calculating pi because he plugged in the Overlord"
10- The comic exhcanged between Garrus and Joker on the bridge of Normandy in ME3
11- Merc banter in Citadel DLC when they see Shep's friends and realize they are over their head.

My fovrite in that regard is Shepard's fake bomb warning during the Thane loyalty mission.
It's such a great impro moment. Sadly, the guy doesn't always show up (I didn't see him during my last PT). I actually always wondered what triggers his appearance, could never figure it out.

Oh, here is the moment for reference:

After completing ME3 earlier today, I still laugh when I see TIM reach down and pull a handgun out of Anderson's butt.

Concerning 1) That Terminal is pretty cool, even when you approach it and the Krogan is still there: "Excuse me, but there a cue forming behind you for the use of this terminal." 

Concerning 2) The paragon reply is pretty cool as well, 'cause the Krogan say something to the effect of "Hand over the Asari." and Shepard is just waving him off "She'll stay with us, thanks." (the dismissive handwave is what makes this line).

Another nice paragon line of Shepard's in ME1 is when you go to Morlan's famous shop on behalf of Dr. Michelle and that Krogan that blackmails the clinic comes along. Shepard goes: "You might not want to shut down a medical facility. What if someone needs treatment? What if YOU need treatment?" Very subtle there Shep.

Completely agree, especially about the terminal. First time I heard him saying 'there's a cue forming behind you', I was torn between laughing my head off or headdesking for losing the element of surprise. XD