If we Are the Aliens

Numbers.

If a couple of white people go into an ethnic eatery together, it still feels foreign.

Chances are your servers and fellow customers are apart of that ethnic group.

I believe that what they want to accomplish is a feeling of a pre-Mass Effect 1. Like a first contact, seeing new aliens for the first time ever.
Remember that in ME1 our characters supposedly knew how an Asari or Turian looked like (although we as the players didn't). It's one of the reasons about why the game feels like a soft reboot of the franchise. And of course the exploration part that people wanted so badly and was nowhere to be found in ME2 and 3. And ME1 exploration wasn't particularly interesting either.
A completely new galaxy, new aliens, and we have no idea what we might encounter around the corner. Those are the basics, I believe.

I actually was thinking how the game aims to achieve some of the things people wanted in the past. A prequel for instance (I never wanted a prequel, mind you). By all means this is not a prequel, but has some of that feeling (finding new planets, first contact with new aliens, etc).
At the same time they are giving us races we already know like Salarians, Asari, Krogans and Humans (duh). So that ought to be "a nice touch" for people who played previous games.
Human centered? It'll work just nice for newcomers, that surely will catch their attention in a game that has "weird" aliens everywhere.

That's the impression I have at least.

More or less.

I don't know how many humans are going to be with us, or how many representatives of the other species from the MW, but there is simply no way they stack compared to what must be present in Andromeda. The alien is going to outweigh the familiar by a wide margin. When more is alien than familiar, you ARE the alien.

Will we get the option to lore dump on native Andromedans while traveling?

If we are the aliens... can we put probes in the Andromedians?

I wish we don't understand Andromedans and that they wouldn't understand us, at least in the begging. The universal translator can't work right from the start. That would make the me feel more alien to Andromeda.

I don't see a problem bringing the Milky Way species along nor do I see how it prohibits us from meeting the Andromeda species. It's kind of like the latest Star Wars movie. The cast of the original trilogy was there to give us something familiar but to also hand off the story to the new characters. With out the MW species we would essentially have the Star Wars prequels and nobody wants that haha.

Here something to think about.

Will MWG aliens be viewed as foreign now that we're in a different galaxy.

In the original ME they made every non-human feel foreign

I would gladly take those potential issues than go bump into an Andromeda alien that is essentially a Krogan or Batarian 2.0, which is to say a rubber forehead human with a few tweaks to their face paint.

It's a lot to ask of BioWare, I know, but if they could somehow make the setting truly alien to us, without insinuating that said state is 'wrong', then they could do an effective job of making humanity feel like the aliens. The problem with the original trilogy of games was that everything was relatable to us, with those scant few outliers being killed off, quickly shoved off camera, turned into joke races, or made to be more like us. Humanity, and our way of thinking and perceiving things, should be a small part of a much larger whole. 

BioWare should also reduce the "human exceptionalism" meter by about a factor of five. We shouldn't be showing up in Andromeda and then immediately setting up shop with all other species deferring to our superior snowflake-iness genetic diversity. We should be scrabbling, looking to other native aliens to help rather than instantly going around solving everyone's problems.

Did your camping trips take 200 years to get to with no way home, and no guarantee there would be any fish at all?

They can start with alien dialogue where we're speaking a human language but any Andromedan we encounter is speaking only Andromedan.  Then as the game progresses, force the player to learn their Andromeda language - i.e. rather than instigating a translator that changes all the Andromeda language to human languages, gradually change over the dialogue selections so that they are in previously learned words of Andromedan and, by the end of the game, have everyone only speaking Andromedan.  Similarly, for the humans (and other Milky Way) species to learn how to do things the Andromedan way - eating customs, sleeping customs, whatever - so that by the end of the game we've adapted to their way of life, not the other way around.

We're the aliens... mmm...

In the other end (the Andromedan point of view) there's a Commander "x", on Nede Emirp, triggering an Human alien beacon, resulting on strange visions of mammals comming to the galaxy, wiping out every sapient species on it... ?