Do you prefer ANDROMEDA? or Milkyway?

I sometimes choose Synthesis. As a mysterious, utopic ending that is never subjected to further development or scrutiny, it's okay. As abhorrent as the Reapers' actions have been, "throwing away" the collective knowledge of so many thousands of species does feel like compounding the tragedy. The Reapers, their killers, are all that's left of those species. It's a weird conundrum. It is easy to imagine that newly peaceful, repurposed Reapers with all of that knowledge could vault everyone forward and upward in stunning ways. As a definitive end to the IP, it works okay.

That's precisely the problem. They never intended to continue ME past the trilogy and the endings show it. Though many have claimed otherwise over the last 6 years, everything Casey ever said before 2012 indicated that ME would conclude with ME3. He and a few others had spent a decade of their lives crafting the world and story. They didn't intend to go further. This is why he felt he could burn the setting to the ground in the finale. He didn't need to leave a workable loom for future stories. Casey ultimately helped lay the foundation of MEA and then took a much needed break.

If they'd originally planned to continue ME, I'm confident that versions of Destroy would've been the ending if the MET. Since they had no further designs, the vastly divergent, open-ended conclusions were used.

As to Control, I agree that it's creepy and ominous. I have only chosen it twice: once to see it, and again to refresh my memory. I'm not a fan. I prefer Destroy. It eliminates the horrific threat that has likely killed quintillions of souls. It preserves the civilizations who have come together in an incredible way. It gives them a chance to build something special, united in a way that would've been previously impossible. They lose the collected knowledge of the Reapers, but they're permanently rid of the killers. Development isn't a straight line, anyway. They'll forge their own future, free from the Reaper threat. We can leave the galaxy free from Catalyst/Reaper manipulation for the first time in untold millions of years. That's the best possible ending in my opinion.

Especially re-imported characters in this case, since NG+ breaks a lot of stuff on import.

I can bet 1$ on it.

I can say I haven't had that experience.  I have only done NG+ with my Ryders and the quest problems have been fixed.  The only time I had problems was with Movie Night because the game imported quest items with NG+ and it caused issues, but that was resolved early.

I never said I was having problems with specific quests.  What I've noticed between playthroughs is an increased tendency for framerate drops and dialogues that don't sound or where the sound gets cut off.  (I don't mean when I drive or walk past the point of the dialogue continue and trigger another dialogue too fast.  I mean when the NPC stands there mouthing words and I hear nothing.)  Framerate drops are just that... motion stuttering or game freezing (usually still temporary though... I've only had a handful of full freezes where I had to restart).  On the Xbox One, I have encountered some restart issues, where the game restarted frozen until I changed Xbox Live profiles with the game running... which resets everything and takes the player back to the main menu.  (I'm lucky I share my Xbox with other people so there is more than one Xbox Live profile on it since even restarting the Xbox without a change in profile done while the game was running did not unlock the freezeup.)

I've done every ending - even the "refuse" ending - and I always settle on "Destroy"...for me, it's ends the mission - eliminate the Reaper threat - definitively.

As for which ending they could canonize to continue the series?  I think both "Destroy" and "Control" are both viable options though would provide you distinctly different world states.

Through "Destroy" EC, you obviously saw that, through time (how many years is unknown), the Citadel and Mass Relays are eventually reconstructed and life seems to return to normal with the threat of the Reapers now in the past.

Through the "Control" EC, the Reapers, controlled by Shepard's consciousness, are still present and hover about the rebuilt Milky Way like an ominous yet silent reminder of what happened during the Reaper Invasion. 

In both of these scenarios, everything is re-set with some slightly different variables evident.

With "Synthesis", I'm not sure how you move forward with that as the canon ending.  Everything is perfect, harmonious, and settled so, what's the threat?  Where is the conflict or drama that could propel us into another series of games? 

I think you really have two viable options to canonize an ending if that's the goal.   

I still don’t think canonization of an ending is wise.

I still don’t think canonization of an ending is wise.

My point is that pointing out a problem with one solution doesn't in itself say anything. You have to establish that another solution is preferable. Or maybe all options are mistakes and the franchise is toast.

Is Andromeda 2 commercially viable now? Would it ever be? I have doubts.