Who do you think will be the protagonist in ME5?

Humanity hasn't been the heart of ME since ME2. 2, 3, and A all could have involved an alien protagonist and the stories wouldn't be hurt in the slightest for example. 
Agree using Liara as the PC would sink the franchise though. 

I'd like for the first quarter be about Shepard post ME3 High Destroy Ending and then it transitions 600 years on the future to male Ryder running into Ark 6 as the Ryder story was getting good at the end on MEA and the final mission blows the ME3 final mission out of the water.

Honestly both can happen, just that when we hit Shepard turn we stay with him for an act and then transition to the Ryder continued experiences, they better not pull a ME2 intro for him and his crew.

We might see more of DA4 on this November and then of ME Next in E3 2022 or in the EA event although we might be getting DA4 promo on next year and just a few more teases of ME Next.

Gamble teased that this is gonna be one hell of a year so i think he's cooking up something either for N7, the game awards or both.

Good, but Gamble has teased a lot of things in regards to ME3 then again, he did honestly admitted before ME3 released that some story bits were cut and were gonna be sold as DLC after release (we should have been more wary of stories like these): samagame.com/en/mass-effect-3-interview-with-mike-gamble/

"Eurogamer: What we have seen in just two levels suggests a narrative evolution of enviable proportions, which is the setting for robust and deep gameplay. The meat on the fire is therefore a lot but despite this we ask you: is there something you would have liked to include in Mass Effect 3 and which, in one way or another, have you been forced to give up?



“We did not finish throwing down an idea that already came to mind a new one, perhaps even better than the previous one”



Mike Gamble: (Smiles) To say that we cut some sequences in a game of this size may seem absurd, but it’s partly true. We did not finish throwing down an idea that we were already thinking of a new one, perhaps even better than the previous one, and that we wanted at all costs to include in the game. You can imagine for yourself how much material we had available! Anyway, I can say that when it hits the shelves next March may not be all: some steps have been cut only temporarily, and will be included in a series of DLC that we are currently planning. True, Shepard’s latest adventure is nothing short of huge but if with some extra content we can make it even more compelling, I don’t see why not!



Eurogamer: Precisely by virtue of such a deep narrative system, a player who has never faced the first two chapters of the saga can approach in complete tranquility Mass Effect 3? Or do you think it is recommended to venture into the storyline in order?



Mike Gamble: I think that Mass Effect 3 can be faced even by those who do not know the past of the legendary Captain Shepard. Of course, the references to the previous episodes cannot be missing, but they will be rather marginal and will not directly affect the script of this episode: even the set of characters has been completely updated, introducing new personalities unrelated to ME 1 or 2. The fact remains that the veterans of the saga will be able to enjoy the narrative continuity of the episodes, with the possibility of importing their own character created and leveled in ME2."


So he also admits of new personalities unrelated to ME 1 and 2 (might mean Vega or change in old characters personalities), so let us keep our hopes down with this same person involved.

I hope they make Commander Shepard the main character again just to piss off the MEA lovers. If they did that today, I would preorder the game.

My Shepard will help rebuild Cerberus returning them to their former glory. Eventually the council will merge with Cerberus. Cerberus will become top dog in the galaxy with my Shepard overseeing everyday operations. ALL HAIL CERBERUS!!!!! ALL HAIL TIM!!!! Humanity #1

This would be perfect for me to be honest. It would give shepard the closure they deserved and get back to ryder who wasn't that bad of a protagonist in my opinion. I am still pissed we didn't get DLC for andromeda.

What would the prologue with Shepard be, and why should it exist when it is an entire galaxy away from the plot of the game?

Both galaxies will likely be involved in the next game up to a certain point I suspect, so having that background will help.