Powers, Skill Trees and Active Abilities (Official Thread)

Tactical Cloak will boost any damage that you deal, including Biotic Charge.

Best setup for bosses is to use a primer that works on any enemy regardless of protections (i.e. Incinerate or Singularity), then using any detonator. In your case, Incinerate to prime and Overload to detonate works pretty well for a fire explosion against any target. However, if the boss still has its shield, then any damage you inflict will only damage the shield until it is fully stripped, so Overload would deal bonus damage but Incinerate and the Fire Explosion would deal normal damage, and vice versa when attacking armor. Another good alternative is to use Combat powers such as Turbocharge to bolster weapons which work well in most situations, or Omni Grenades and other powers that can be specced for Anti-Shield or Anti-Armor.