What is the cause of people's worry? (if you are)

Now, truly this is an interesting topic and an important prompt for the Mass Effect Universe in general.
Personally, I must admit I’m riding a worsening spiral of skepticism regarding Andromeda: the reasons why are detailed below, but mainly it appears to me this new chapter is going to be filled with fig leaves, needed to cover some of the problems it has. In this regard, I hope to be colored surprised at launch, but something tells me it will not be so.
In length:

1) The more we know about Andromeda, the more the tone seems set to be “lighter”, “funnier”, “less grim” than the first trilogy. WHICH IS NOT A BAD THING PER SE: though, I question the way it has been achieved.
Specifically, companions who can’t die by default. Or the renounce to a morality system (or at least, I perceive it to be so), with less consequences, story wise, on the “how” and “why” some decisions have (and could have) been taken during the course of the game. These 3 elements together appear to me almost as the base for the plot of a Saturday morning sci-fi cartoon, with all that innocence and insufferable plot armor naivety (Peebee I’m looking at you, with your midriff bare on a planet filled with LAVA). The kind of which can be summarized with:
“We will have an happy ending because we are the good guys” where the self-righteousness of this aspect is justified by default. Screw the “earn your happy ending”: what matters if the players don’t relate anymore (or less) with the story and don’t sympathize with the characters?
In DAI, Varric explains: “If you love your characters, you make them suffer.”
And it’s the goddammit truth, because the concept preys on the natural empathy of the human species. Why again should be a good idea renouncing the possibility to earn your reward story wise?
Especially when it was revealed characters’ plot amour is thick enough from the start?

Granted, knowing Bioware, Andromeda can be a great sci-fi cartoon, but I fear the potential shallowness of the plot that it implies. And frankly speaking, the main reason why I loved so much the trilogy of Mass Effect was the plot and the deep universe around it: Sovereign and the truth about the Reapers were delivered in the best way possible in ME1, and ME2 and 3 worked only thanks to the “How” that revelation was given to the players. Skipping (just because) the chance to try and recreate the same mind blown reaction in the players, the same suspense and the same incredible atmosphere, would be as squandering the reputation Bioware earned as “game makers”, imo.
And the lack of a “relatable” plot becomes only that much apparent, if what you offer instead are better sex scenes. Ok, they are great, and the less prudish the better (let’s raise our middle fingers to the bigots) but in my humble opinion, if you buy a Bioware game just to masturbate, you are an imbecile.

2) Dumbed down combat system.
There is a glaring difference between streamlining a concept and dumbing it down. Mileage may wary among each and every single one of us, but imo, Andromeda combat system, as we have seen it, is dumbed down from ME3.
You can try and sell me the overpowered combos theory, the console friendly approach or the more fluid action to compensate, but I rest my case: imo, Andromeda combat system has been made as it is, to create a copy to the multiplayer experience. Profiles swapping is functionally USELESS, if bonus from one can’t be carried over when swapping: pets despawn (among the others) and I’m sure as hell that when I’ll pop barrier and switch over, the shield bonus will be lost too. So, this gimmick is again a fig leaf to cover the fact that yes, we have only 3 powers at the same time in every combat situation, with all the limits this implies.
It disturbs me more the fact that someone (many) tried to hid it, instead of being honest with this direction of gameplay design, and even then the results are quite apparent: the less we talk about the implication in universe and lore wise about a brain plugged AI able to reconfigure your very body functions on the fly (more or less), the better.
For what hellish reasons biotics should not be accessible while using tech powers?
And where the hell the eezo came from, if our Ryder wasn’t a biotic before Andromeda?
And so on and on and on…

But wow, we can jump jet now! The rest of the concept around our main character during combat doesn’t make a shred of sense in universe, but we can jump so hiiiighhh!
Fig leaves to hid the leveling of the game experience to the lowest common denominator: multiplayer.
Which again, it’s not a bad thing per se: but it could have been done a lot better imo, enriching the experience with smarter mobs (for instance) instead of the usual bullet sponges.
Another squandered occasion.

So my impressions on both plot and combat are less than favorable at the moment (of course, based on the material we have at the moment). What instead for the moment I do appreciate are the characters (Peebee not included so, 5/6): it seems that in that regard, Bioware is still willingly to create companions coherent with all the information provided in universe and make them great, without compromises.
Bravo! This is how it should be!

***

After all of above, I admit I’ll buy Andromeda, because:
a) Even in their worst days, FOR NOW, what Bioware cobbles together is still better than most of what other thinks it is their best (even if the difference is lessening)
Because I WANT a first-hand experience to have an opinion I can discuss (here, there, doesn’t matter).
c) Because I love Sci-Fi (and I mean it past the point one begin writing it) and I’m partial to everything with space ship and technological dilemmas, when correctly delivered. I really hope Andromeda will be one of those.

...  ... 

I want to make a joke here... but... hmm... I feel it might be too obvious. So I'll just be subtle about it and don't mention anything




Anywho... 
I'm mostly worried about the romances, specifically their by now obvious attempt at censoring anything m/m related, to which my general answer is 
After the Peebee video yesterday, I'm also seriously concerned about the quality of writing for any character if she and her mission are an indication of things to come.
The avalanche of bugs and errors are generally a Bioware signature, so that's not really a concern, more like realism.

So yeah, other than romances, characters, story and technical issues, looking forward for the rest of the game 

I'm mostly worried that the internet hate will prevent any kind of sequel, regardless of how good a game Andromeda is.

Story and villain, really.
These are my main concerns.

And it's already been mentioned by PC Gamer that villain's introduction is very weak.

In that recent gameplay there seemed to be a lot of auto dialogue. I hope it's not like that when the game ships. Besides that, side quests. I hope they're not like DAI.

1) I see the concerns you state and the possibilities that arise with the squadmates all having plot armor. However suffering does not simply mean death, the gripping struggles squadmates may go through will also strengthen your ties. Death is usually one of the best ways a character can suffer, what if a squadmate nearly dies and is then crippled? You wouldn't be able to take them on missions because of their health, however they would still be living and suffering. On another note, just because the squadmates don't die it doesn't mean many, perhaps even relatable, NPCs can die. 

2) The system derived offers more choice and lots of unique playstyles... I can see your arguement of only having 3 abilities, however you do have access to four profiles that you can switch between mid-combat. Bonuses can actually be carried over, well more the passives in each tree. The profile bonuses themselves do change when you switch, however you could be a soldier with biotic passives, such as barrier.
The eezo thing was also a question I had, though this AI was probably made and installed before the journey to Andromeda.

I'm pretty confident I'll enjoy the game so I feel some level of excitement but if I something was a bit of a concern that it would be that the game might not be as polished as I'd hope

One thing that has me curious after watching the various game play vids is whether we'll be able to change the weapon load out for our squad mates. During actual game play it looks like they only have one gun, which was also highlighted in their character profiles (Cora has a shotgun, Peebee has her revolver pistol, Drak has his shotgun with the bayonet).

Also a pet peeve that I've had since ME2 was the "insert weapon" during cutscenes which looks like will be making a return in Andromeda.

Overall though I'm very excited for the game, even though there's been a lot of issues being pointed out I'm staying optimistic that they'll be covered with the day one patch and any other issues I'll be able to overlook once I start playing.

I never meant "suffering" as death of one character: after all, there are fates worse than death.
Still, as far as I know, all of these personal struggles will not be there in Andromeda, because it is lighter and “fluffier” than the trilogy.

From the trailers:
“We are explorers, not soldiers.”

Yeah, but still the fate of 20’000 people weights on our shoulder as Ryder: being this the case, are we really sure a lighter theme is “proper” and “coherent” for the story? Imo, not so much.

Regarding the bonuses, I intended “ability bonuses” as from powers like barrier (or reave from ME3) or pets like drones/remnant tech. Which, as showed in the combat demo, despawn on profile swapping: I’m assuming barrier “shield bonus” (or reave damage absorption) will do the same.
It’s true though: we can have bonus biotic recharge time while using combat ability. Nevertheless, it seems functionally useless, when I can’t enhance my playstyle with it: I must swap abilities again.
Yeah, it is possible to combine 3 powers whatever we like among 3 areas: but only 3 at a time, which I see as a limitation, and at most a mean to make transition to multiplayer seems seaming less. Hell, considering companions AI, the multiplayer experience will be better than the single player this time. And for a game like ME, this is wrong on multiple levels: first and foremost, why the single player experience should be balanced with the same canons used on multiplayer?
At this point, hack and chop ME as a MMORPG: if done correctly, this could have been an interesting idea. But leave the multiplayer and the single player separated: they will never be the same thing. They can't be.

This right here is my biggest fear. I've always been a firm believer that the DAI quests wouldn't have been viewed with such contempt if we actually got to see the characters we were picking/leaving flowers for. Heck FFXV's side quests were much worse but I still felt overall more purposeful because I actually got to see the characters and enjoy their character design, and overall feel actually part of the world, instead of a guy doing pointless chores to get to the good stuff. 

Take that quest in DAI for example, where you have to drain the lake to get to the rift, and you meet that couple in the dam. In previous DA games that would be a lulzy, memorable cutscene. In DAI however, we get to see a few dodgy animations from afar and that's our lot. 

I'm not VERY worried. In fact, I'm pretty excited. But if anything has me leery, it's the overall story. Just not sure what it's actually going to be LIKE, and if I'll enjoy it.

That being said, my least favorite Bioware game has still been a solid investment returning many hours of entertainment, so I'm preordering the bajeesus out of it. And Mass Effect 2 has shown me that I can forgive a stupid-ass story for fun characters and good gameplay, even if I'll mutter on occasion. And I'm not worried about the characters and my potential spacefriends from what we've seen. Hearing what we have about friendship arcs has got me really hyped. And so has what we've seen of combat, because I'm an idiot who loves vanguard charge and making poor melee-based choices. It looks like the game will let me employ shenanigans. And that matters to me.