Would you be ok if they went back to the Milky Way?

I agree about redoing ME3. If they do, put in the content that got cut because they didn't have enough time.

Then remake the trilogy. In ME1, the player learns about the trip to another galaxy. Maybe even have Shepard meet Garson. When heading to the moon to deal with the rogue ai thing, Joker can mention the size of the ship the project is building. During the events of ME2, the player learns that some unnamed people donated a lot of resources to help get the project underway. The ships takeoff after the collectors have been dealt with. The player, or rather the characters in the game, don'tneed to know its some top-secret benefactor that donated the resources to get the ships out of the Milky Way before the reapers arrive. It can be assumed, but for all anyone knows, its all about exploration in Andromeda

Milky Way is played out. I was to know what happens in Andromeda.

A "Star Trek Voyager"-style perilous journey home might be OK, but I'm not sure how that would work in dark space. And they would have to come up with a reason.

For some reason the First Contact War doesn't really do it for me. Maybe because it's small potatoes compared to the high stakes in all the other games in the series. And because we already know how it ends. And you wouldn't really be able to be a freelancing space commando, you would have to be a soldier in an army.

You seem to forget that Shepard's story is confined to the trilogy. It has to end somewhere. Otherwise, it just keeps going, and going, and going...

At the end of ME3, you make your final decision which seals the fate of the trilogy. Like writing the last line in a book.

I get the feeling this is one of those debates that depends on how the individual poster is defining "relevance."

All true, but Shepard's actions in the large scope of the franchise are now irrelevant.  The Milky Way is just "over there" now

The problem is they were trying to give the vocal community members what they were saying they wanted. They gave us choices that shaped the game world, now they have to go in another path.  I think where we are can be attributed to at least party 'be careful what you wish for".  Now it does seem BioWare trying to keep the scope of things smaller at least at this point so the future of entire species aren't something we decide.

That would be true if Shepard's "final line" had not fundamentally altered the entire galaxy.  As such, no further story can be told there without that story intruding on the new one.

As such, the next game to either 1) canonize an end-state to the trilogy, or otherwise somehow render Shepard's actions irrelevant ("it was all a dream", etc) or 2) relocate someplace where Shepard's choice does not impinge on what's happening, thus rendering that story irrelevant for MEA's purposes. 

Thus we either stay in Andromeda, where Shepard's actions are irrelevant to what's happening there, or return to the Milky Way, and have Shepard's actions rendered irrelevant, because we CAN'T tell a story there otherwise.

In a sense.  But I think the existence of governments, species, even entire planets make for pretty "relevant"  states.

Didn't that ship sail after Rannoch? (Not Tuchanka, because the cure/no cure status is easy enough to subsequently change.)

It's less convincing to weave around Rannoch (can rebuild the geth / there were still some quarians elsewhere). There are obviously problems with that but it's not impossible. The ending differences are more insurmountable. Making galaxy-changing choices was really stupid.

You may not have a problem with it, but I do not see it ever happening.