More likely that we're heading back to the Milky Way?

Did you notice that you have only one quote from ME1 and most are from ME2 - "The council can kiss my ass." and then you mention the action of hanging up on the council.

BioWare insists Mass Effect is a human story. We will not be able to play as non-human in a main game series, not until total change of leadership in BioWare or some other studio gets to make an ME game.

I'm sorry, but it's not happening with current BioWare mentality over Mass Effect.

Anyone else think that, with the very tepid reaction by most ME fans and the general gaming population/media, it is quite possible that for the next Mass Effect title to be set back in the Milky Way?

Before Andromeda released, I was fairly confident that we'd see several games set in the Andromeda galaxy, telling the story of the Ryder family as they seek to find a new home for the Citadel races. But with the unexpectedly low sales and review scores, everything seems to have changed on Biowares end. We still don't know for sure, but it seems as though Montreal has been downsized from a full studio and repurposed as a supplemental team once again. I think it is quite possible Bioware may play it safe on their end, by releasing a game set in the more traditional and well-liked setting of the Milky Way. That way, they can use tried and true settings, fan favorite characters and races, and iconic elements from the trilogy (ME relays, etc.) to win back hardcore fans.

What do y'all think?

I absolutely agree... there are more examples of "renegade" lines in ME1 than were cited.  What I was implying, however, is that more people seem to really remember the renegade moments of ME2 as opposed to ME1. 

I would not be surprised (if we get another Mass Effect game) if they continue with the destroy ending as cannon from ME3 let’s say 100 years after so we stay in the Milky Way with a new option for a PC to choose a different race and not just human.

There are zero issues with going back. The endings can be ignored in favor of something new that doesn't destroy the galaxy. Yes, it will be a retcon, but it will be a retcon of something shitty into something good that BioWare can work with. They already retconned the fuck out of the Trilogy story to enable Andromeda's retarded intergalactic voyage anyway.

There are zero issues with going back. The endings can be ignored in favor of something new that doesn't destroy the galaxy. Yes, it will be a retcon, but it will be a retcon of something shitty into something good that BioWare can work with. They already retconned the fuck out of the Trilogy story to enable Andromeda's retarded intergalactic voyage anyway.