If Mass Effect gets another game, what would you want?

Ick. Pass.

A Mass Effect game in a galaxy that's less than 1% explored.

But I'll come up with a compromise, Andromeda 2 without the idiots of the Tempest minus Drack.

Let me fix that for you since well...

...you know.

I honestly wonder if you were this critical of Shepard throughout the series before ME:A. I'm willing to bet you weren't.

of course not. But A. I quite enjoyed Shepard. But their time is done. Time for someone else to take charge. B. Shepard was my first RP protagonist. As such i did not realize their weaknesses. C. Ryder raised the bar for protagonist in ME games.

Among recent Bioware protagonists for me it goes from best to worst:
1. Inquisitor
2. Ryder
3. HoF
4. Shepard
5. Hawke

It can take place in Andromeda, but not with the characters of MEA. I'm sorry but there is simply no way to resurrect the absolutely awful and uninspired story of Mass Effect Andromeda.

There is no way you can make the Kett threatening in any way or the Angara interesting. The squad is also a pale imitation of the original trilogy. I would just completely forget about that story and make the next game about the Quarian ark. You play as not the Quarian pathfinder, but just an engineer/scientist/soldier or some other class who has to take action once your ark encounters trouble and gets spaced. Make the game take place in a completely different area of Andromeda, one that is much harsher and tougher. One that has some actually interesting races that seem way more alien and unnerving than the ones we saw in MEA.

Make the environment conditions and the planet themselves be the biggest obstacle, not a shooting gallery of generic aliens. Make the game more linear in the sense that you remove all the clutter of exploring giant empty areas, but instead you are constantly in focused story related instances and you have to make important decisions more frequently. Quality over quantity (the opposite of MEA). That is what makes Mass Effect the great franchise that it is. A compelling and ambitious sci-fi story, that takes place in an immersive world. And you can make that world immersive without cluttering it with pointless and dragged out sidequests in a giant bland looking area.

A personal, intimate story of one of the Kett Rockheads and his trials in search of his identity: Why does everyone look like me? Why?!

Exactly, that's, for me, the main problem of Andromeda. They tried to develop the characters, but all of them are pretty pathetic and epic fail copies from previous characters. Vetra is "female Garrus", she even has the visor, just like Garrus, Drack is older Wrex (hahaha, I'm here to say badass things and tell war stories), Cora and Liam are the two initial stupid human characters we couldn't care less about (what a pity we couldn't let one of them, or even both of them die in Andromeda), SAM is a far less interesting EDI, etc. Cora and Liam are the worst, IMO. Liam is an absolutely idiot and Cora can't say 10 words without one of them being "asari". 
If they work REALLY hard they could fix some of them and give them more depth, but I don't see it happening, it's better to write all characters from scratch

And of course, BRING BACK RENEGADE OPTIONS, I DON'T WANNA BE NICE ALL THE TIME! I just missed a renegade interruption that allowed me to punch Tann in the face for his racism. 
One of the hardest options was when I had to tell Liam either "You're an asset to the team" or "It's good to have you here", because both of them are absolutely not true. That's one of the things that made Ryder the worst main character EVER on a Bioware game. 

IF MASS EFFECT GETS ANOTHER GAME, WHAT WOULD YOU WANT?
Faces that don't look so tired.

I prefer they continue Andromeda. Lots of untapped potential.

I could support it.