Things working against a possible Ryder series sequel as of right now

What are you going to change?  Are Ryder and the crew all of sudden going to be grown up and you're going to change the overall tone of the game?  Are you all of a sudden going to add a bunch of new races to the game for people who didn't like only having one new race?  Is the terraforming going to be done in a couple of years, or are the worlds going to still be barren and empty.  Are you going to give the Kett a complete overhaul to make them less of a joke. There were things people didn't like about the game that you can't really change.  If you're making a direct sequel it means that people liked what they got the first time and you're giving them more of the same.

People had issues with this game past animations and bugs.  

Did the krogan rebel causing the other species to gang up on them to put them out of their misery, and then give the planet to the rachni? Or did the council species wait for the rachni to breed millions to have them invade Tuchanka wiping out the krogan? If not, I don't have an explanation why the rachni are on Tuchanka. I would believed they would go back to where they were before the reapers showed up after the reapers were destroyed.

Another is for their help in destroying the reapers, the krogan were given a planet that was in better shape than Tuchanka. Once the krogan moved to their new home, the rachni moved to Tuchanka.

Whatever happened, that scene looks to be far into the future.

I tired of the whole one cluster excuse.  If the Kett can make it there, and we can migrate there, you can write a story for other races being there.  They could have been running from the Kett empire.  They could have moved there because the scourge destroyed their old system entirely, and hadn't made it's way there when they came.  Also, if Andromeda had several new races with no explanation players would not have been screaming about how unrealistic it was having more than one new race in a cluster, let's be honest here.  People made that up as an excuse once the criticism started.  Before the game came out no one was saying, there better not be too many new races in the game with it all taking place in one cluster.

Also we did not mow down Collectors, they killed you in the first scene to set the tone, and then you spent an entire game building up your strength before you faced them again.  Whenever ever you went onto a collector ship you sneaked on, did what you had to do and escaped on the Normandy.  You didn't take it over or completely or run them out.  In the OT the games had fodder enemies like Geth in ME1, mercs in ME2, and husks in ME3, so that the main enemies in the game could keep some sort of mystique about them until the end.  You weren't killing collectors every mission and side mission, they threw out hordes of mecrs for that.  Kett were both fodder and main enemy and you curb stomped them all game.  But even the story as written, you overran the Archon's flagship and stole back the Salarian Ark, overran their base on Voeld and destroyed it.  Took down their fleet with a bunch or drones.  Had them run off Kadera entirely.  Aside from activating the cannon on Horizon after the Collectors had mostly finished with what they were doing, when did you do stuff like this to them?

Kett don't even have super fast transport, they use a version of arks, so how long before reinforcements arrive?  But let's say the Kett do make it there with their real force.  You still only have 200K people, not even all military and no war ships of any kind. 

It would be asking a lot for players who had a problem with the first game to pick up a sequel.  I'm sure EA/Bioware looked at the last time people played the game, how many times they finished it, how many finished it, and compared it to other releases.  Dragon Age 2 was rushed and got criticized for it, but it even got a couple of DLCs.  Just having Andromeda in the title would probably cause a lot of people to not buy it.  If they didn't like the characters, the story, the premise of the first game, why would they buy another with the same name?  The name itself is toxic at this point.

You're tired of it?  Have you, I don't know, looked at the state of the planets in that cluster?  Where, exactly, are all these races supposed to be living?  On that asteroid belt that was meant to be the turian golden world?  On Kadara, where the water is toxic?  On Habitat 7, where the rocks float and the planet discharges electricity at random times and locations?  Havarl, where the plant and animal life was constantly mutating out of control?  Maybe that planet covered entirely in ice?  It's like you just want to ignore what's inconvenient.  The only place we saw that was perfectly viable was Aya and we know the Scourge itself kept the planet somewhat hidden, even from the kett.

Yes, the Collectors killed me on the SR1.  Every encounter thereafter had me killing them.  I mowed them down.

No, kett don't have super fast transportation.  Can you tell me exactly where they are during the events of MEA so we can clarify whether they can arrive immediately or if it will take some time?  What's that?  No, you can't, because we don't know?  Sounds like it would be perfect to allow a slight passage of time (2 years between ME1 and ME2, and roughly 6 months between ME2 and ME3) to allow for them to arrive.

BTW, I don't claim MEA is perfect in every respect.  I had a lot of issues with it myself.  I just don't think it's the clusterfuck the loudest people want to claim it is, nor that it was so bad that they can't improve on it.

Also, if you're going by how BioWare feels about the "last game", they have zero reason to go back to Shepard or the MW, given how much bitching and moaning was done about the endings.  Tbh, if social media were on the same level in 2012 as it was in 2017, I think ME3 would have been utterly annihilated by critics.

Technically there was more than one race in Heleus, sadly one was wiped out by the Scourge, you can see their primitive villages in the galaxy map. The other left behind only a torpedo.

The problem is, advancing too far ahead completely ignores probably the most significant, lingering plot in the game, which is the Mysterious Benefactor. If you're going to ignore that, then you may as well wipe the slate clean.

Now, if the kett are that powerful, I guess that does make them a worthy threat after all.

And, I'm sorry, but escaping or otherwise, those Collectors in my path were still dying in droves, including the ones that were possessed by Harbinger. I don't have to be there on the attack. I just have to be the one doing the killing while they are doing the dying. And that's what happens. My point is, they die just as easily as kett, except when they do an attack on an unexpected attack on an unprepared vessel.

World state 1: The salarains are awesome and created another genophage(vs we never cured it in the first place) so the krogans are no longer flourishing, the reapers rebuilt and then left(vs it was lots of hard work but we eventually rebuilt), cybernetics are the norm but most aren't visible vs we are all synthetics because someone picked the worst option.

World state two:  Krogans weren't extinct but took heavy casualties, the combined forces eventually freed Tuchanka but you never visit to see it(so both of which you only know of from lines of dialogue and the small number of Krogan you always see in the games), a remorseful Quarian rebuilt the geth from data files found on the home world.(as opposed to not destroying them in the first place which is just crazy talk)

Bioware said before MEA was ever launched that it was a singular game and not a series like MET.  They didn't promise anything outside of MEA.  They weren't supposed to leave any unanswered questions at the end.  I'm sure the DLC that had planned for it would have filled in the gaps, but since they cancelled them, your left with how the game ends.

I'm fine with the ME series being dead.  I don't think Bioware is capable of creating something that is on par with the MET and I have seen enough damage done to the IP already.

A galactic society similar to the Milky Way isn't really in the cards for Andromeda, not without something akin to the relays. But a huge time skip isn't really necessary. But really, this is just one cluster, one that is kind of murky in what's actually in it due to the scourge. It would be like setting the entire game in the Hades Gamma cluster then going forward in time to fill it up without really knowing what's beyond it. The kett subjugated a lot of species, so the galaxy probably already has a bit of a galactic society, albeit one probably at war with the kett. 

As for the Collectors, I suppose the biggest difference is that the Collectors have no characters at all. The thing I found disappointing was that every time one spoke, it was just Harbinger speaking remotely. Meanwhile, we get the impression that they actually speak to people and buy and sell things, but for us they were never entities in themselves that can be interacted with outside of gunfire. That they turned out to be protheans was cool, but they were basically just husks with weapons training. Once their mystique was lifted, they just became basic monsters again. In terms of gameplay, they at least had better enemy variety, particularly the Praetorian, which to me was always the coolest baddie we fight with in the game, and the only enemy that genuinely made me nervous to battle in any ME game outside of that damn Krogan battlemaster in ME1. 

The only time they had trouble with the scrouge is Aya. The other locations, outposts and Nexus, would be easy targets for the kett. Since they have seen the memories of little Ryder, they know what she/he knows. I can see them being able to get around the scrouge to reach Aya. The only time the scrouge gave them problems was at Meridian. Take that away, little Ryder and others would have been wiped out. The Initiative have nothing to stop the kett from attacking. Meridain is an unknown. How long will it take to know its full potential? If the kett decide to attack right after the events of MEA, something I would do, it won't matter what Meridian's capabilities are.

Yep, the plan wasn't a trilogy but multiple games that work off the previous one to further the overall Andromeda story.

The only thing the "Mass Effect Andromeda" universe needs is a re-focus on solid world building and character development and they could accomplish this quite easily with the foundation established with the first game carried over into a sequel.   

I'm certainly not fine with it being dead. There's hardly any scifi RPG games out there as it is. One less is not a positive in any sense.