Who's still doing playthroughs of ME:Andromeda?

If you want to do a main mission focused playthorugh, it is easiest to do it as a NG+.  Just start a game re-importing your Level 70 Ryder and you won't have to worry about how much you level up during the game since the enemies will only level up with you.  The resources and items you collected will carry over (although your inventory capacity will drop back down to 100 (so you'll probably have to deconstruct some things so that you're not starting the game overloaded and unable to collect anything new).  Since your minerals and other crafting supplies and augments carry over, it's easier to explore using different weapons and armor with NG+ as well.

You do lose out on missions that require the Hyperion to complete, unless you do those ones before the final one.  One thing I was surprised was how I felt about not having completed the Ryder's Family Secrets quest.  There were little dialogue changes that occurred as a result that suited the type of Ryder I was role playing quite well.  Certainly, there were a number of writing improvements that could have been made (Mass Effect has never been the equivalent of War & Peace in my mind and has always been just a very good game).  For fun, I would have liked some more renegade-like options for Ryder,. since the lack of them does mean ME:A is not quite a versatile as the OT.  Still, I certainly don't regret buying the game at all. and I've enjoyed every single one of my 7 complete playthroughs.  I imagine I might have another 2 or 3 playthroughs left in me before I pack it away for an extended hiatus.  If Bioware do ever change their minds and decide to produce a sequel, I'll be quite willing though to reload it and play it yet again before that sequel releases.